ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus
Identifieur interne : 000781 ( Pmc/Checkpoint ); précédent : 000780; suivant : 000782ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus
Auteurs : Zhiqiang Wu ; Li Yang ; Xianwen Ren ; Junpeng Zhang ; Fan Yang ; Shuyi Zhang [République populaire de Chine] ; Qi JinSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2015.
Abstract
Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)–like CoVs (SL-CoVs) were identified from
Url:
DOI: 10.1093/infdis/jiv476
PubMed: 26433221
PubMed Central: 7107392
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Xianwen" sort="Ren, Xianwen" uniqKey="Ren X" first="Xianwen" last="Ren">Xianwen Ren</name><affiliation><nlm:aff id="af1"><institution>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhang, Junpeng" sort="Zhang, Junpeng" uniqKey="Zhang J" first="Junpeng" last="Zhang">Junpeng Zhang</name><affiliation><nlm:aff id="af3"><institution>State Key Laboratory of Estuarine and Coastal Research, Institute of Estuarine and Coastal Research, East China Normal University</institution>,<addr-line>Shanghai</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yang, Fan" sort="Yang, Fan" uniqKey="Yang F" first="Fan" last="Yang">Fan Yang</name><affiliation><nlm:aff id="af1"><institution>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhang, Shuyi" sort="Zhang, Shuyi" uniqKey="Zhang S" first="Shuyi" last="Zhang">Shuyi Zhang</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>College of Animal Science and Veterinary Medicine, Shenyang Agricultural University</institution>,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Qi" sort="Jin, Qi" uniqKey="Jin Q" first="Qi" last="Jin">Qi Jin</name><affiliation><nlm:aff id="af1"><institution>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation><affiliation><nlm:aff 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type="main">ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus</title><author><name sortKey="Wu, Zhiqiang" sort="Wu, Zhiqiang" uniqKey="Wu Z" first="Zhiqiang" last="Wu">Zhiqiang Wu</name><affiliation><nlm:aff id="af1"><institution>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yang, Li" sort="Yang, Li" uniqKey="Yang L" first="Li" last="Yang">Li Yang</name><affiliation><nlm:aff id="af1"><institution>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ren, Xianwen" sort="Ren, Xianwen" uniqKey="Ren X" first="Xianwen" last="Ren">Xianwen Ren</name><affiliation><nlm:aff id="af1"><institution>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhang, Junpeng" sort="Zhang, Junpeng" uniqKey="Zhang J" first="Junpeng" last="Zhang">Junpeng Zhang</name><affiliation><nlm:aff id="af3"><institution>State Key Laboratory of Estuarine and Coastal Research, Institute of Estuarine and Coastal Research, East China Normal University</institution>,<addr-line>Shanghai</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yang, Fan" sort="Yang, Fan" uniqKey="Yang F" first="Fan" last="Yang">Fan Yang</name><affiliation><nlm:aff id="af1"><institution>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhang, Shuyi" sort="Zhang, Shuyi" uniqKey="Zhang S" first="Shuyi" last="Zhang">Shuyi Zhang</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>College of Animal Science and Veterinary Medicine, Shenyang Agricultural University</institution>,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Qi" sort="Jin, Qi" uniqKey="Jin Q" first="Qi" last="Jin">Qi Jin</name><affiliation><nlm:aff id="af1"><institution>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</institution>,<addr-line>Hangzhou</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)–like CoVs (SL-CoVs) were identified from <italic>Rhinolophus</italic> bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from <italic>Rhinolophus sinicus</italic> have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name></author><author><name sortKey="Fisher, Mc" uniqKey="Fisher M">MC Fisher</name></author><author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ge, Xy" uniqKey="Ge X">XY Ge</name></author><author><name sortKey="Li, Jl" uniqKey="Li J">JL Li</name></author><author><name sortKey="Yang, Xl" uniqKey="Yang X">XL Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z Shi</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, Pa" uniqKey="Rota P">PA Rota</name></author><author><name sortKey="Oberste, Ms" uniqKey="Oberste M">MS Oberste</name></author><author><name sortKey="Monroe, Ss" uniqKey="Monroe S">SS Monroe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, B" uniqKey="He B">B He</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author><author><name sortKey="Ren, X" uniqKey="Ren X">X Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Song, Hd" uniqKey="Song H">HD Song</name></author><author><name sortKey="Tu, Cc" uniqKey="Tu C">CC Tu</name></author><author><name sortKey="Zhang, Gw" uniqKey="Zhang G">GW Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Cy" uniqKey="Chen C">CY Chen</name></author><author><name sortKey="Ping, Yh" uniqKey="Ping Y">YH Ping</name></author><author><name sortKey="Lee, Hc" uniqKey="Lee H">HC Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Law, Py" uniqKey="Law P">PY Law</name></author><author><name sortKey="Liu, Ym" uniqKey="Liu Y">YM Liu</name></author><author><name sortKey="Geng, H" uniqKey="Geng H">H Geng</name></author><author><name sortKey="Kwan, Kh" uniqKey="Kwan K">KH Kwan</name></author><author><name sortKey="Waye, Mm" uniqKey="Waye M">MM Waye</name></author><author><name sortKey="Ho, Yy" uniqKey="Ho Y">YY Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keng, Ct" uniqKey="Keng C">CT Keng</name></author><author><name sortKey="Choi, Yw" uniqKey="Choi Y">YW Choi</name></author><author><name sortKey="Welkers, Mr" uniqKey="Welkers M">MR Welkers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="He, Yq" uniqKey="He Y">YQ He</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">jid</journal-id><journal-id journal-id-type="hwp">jinfdis</journal-id><journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26433221</article-id><article-id pub-id-type="pmc">7107392</article-id><article-id pub-id-type="doi">10.1093/infdis/jiv476</article-id><article-id pub-id-type="publisher-id">jiv476</article-id><article-categories><subj-group subj-group-type="heading"><subject>Major Articles and Brief Reports</subject><subj-group subj-group-type="category-toc-heading"><subject>Viruses</subject></subj-group></subj-group></article-categories><title-group><article-title>ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Zhiqiang</given-names></name><author-comment content-type="other"><title>a</title><p>Z. W., L. Y., and X. R. contributed equally to this work.</p></author-comment><xref ref-type="aff" rid="af1">1</xref><pmc-comment>zdsys@vip.sina.com </pmc-comment>
<xref ref-type="corresp" rid="d984e145"></xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Li</given-names></name><author-comment content-type="other"><title>a</title><p>Z. W., L. Y., and X. R. contributed equally to this work.</p></author-comment><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ren</surname><given-names>Xianwen</given-names></name><author-comment content-type="other"><title>a</title><p>Z. W., L. Y., and X. R. contributed equally to this work.</p></author-comment><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Junpeng</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Fan</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Shuyi</given-names></name><author-comment content-type="other"><title>b</title><p>S. Z. and Q. J. contributed equally to this article and are co-senior authors.</p></author-comment><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Jin</surname><given-names>Qi</given-names></name><author-comment content-type="other"><title>b</title><p>S. Z. and Q. J. contributed equally to this article and are co-senior authors.</p></author-comment><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib></contrib-group><aff id="af1"><label>1</label><institution>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></aff><aff id="af2"><label>2</label><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</institution>,<addr-line>Hangzhou</addr-line></aff><aff id="af3"><label>3</label><institution>State Key Laboratory of Estuarine and Coastal Research, Institute of Estuarine and Coastal Research, East China Normal University</institution>,<addr-line>Shanghai</addr-line></aff><aff id="af4"><label>4</label><institution>College of Animal Science and Veterinary Medicine, Shenyang Agricultural University</institution>,<country>People's Republic of China</country></aff><author-notes><fn id="AN1" fn-type="con"><label>a</label><p>Z. W., L. Y., and X. R. contributed equally to this work.</p></fn><fn id="AN2" fn-type="con"><label>b</label><p>S. Z. and Q. J. contributed equally to this article and are co-senior authors.</p></fn><corresp id="d984e145">Correspondence: Q. Jin, MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China (<email>zdsys@vip.sina.com</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="epub" iso-8601-date="2015-10-03"><day>03</day><month>10</month><year>2015</year></pub-date><volume>213</volume><issue>4</issue><fpage>579</fpage><lpage>583</lpage><history><date date-type="received"><day>4</day><month>8</month><year>2015</year></date><date date-type="accepted"><day>24</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail <email>journals.permissions@oup.com</email>.</copyright-statement><copyright-year>2015</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="jiv476.pdf"></self-uri><abstract><title>Abstract</title><p>Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)–like CoVs (SL-CoVs) were identified from <italic>Rhinolophus</italic> bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from <italic>Rhinolophus sinicus</italic> have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.</p></abstract><kwd-group><kwd>severe acute respiratory syndrome coronavirus</kwd><kwd>origin</kwd><kwd>bats</kwd><kwd>ORF8</kwd></kwd-group><funding-group><award-group><funding-source><named-content content-type="funder-name">Program for Changjiang Scholars and Innovative Research Team in University of China</named-content></funding-source><award-id>IRT13007</award-id></award-group><award-group><funding-source><named-content content-type="funder-name">National S&T Major Project “China Mega-Project for Infectious Disease,”</named-content></funding-source><award-id>2011ZX10004-001</award-id><award-id>2014ZX10004001</award-id></award-group><award-group><funding-source><named-content content-type="funder-name">National Natural Science Foundation of China </named-content><named-content content-type="funder-identifier">http://dx.doi.org/10.13039/501100001809</named-content></funding-source><award-id>81501773</award-id><award-id>31570382</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Jin, Qi" sort="Jin, Qi" uniqKey="Jin Q" first="Qi" last="Jin">Qi Jin</name><name sortKey="Ren, Xianwen" sort="Ren, Xianwen" uniqKey="Ren X" first="Xianwen" last="Ren">Xianwen Ren</name><name sortKey="Wu, Zhiqiang" sort="Wu, Zhiqiang" uniqKey="Wu Z" first="Zhiqiang" last="Wu">Zhiqiang Wu</name><name sortKey="Yang, Fan" sort="Yang, Fan" uniqKey="Yang F" first="Fan" last="Yang">Fan Yang</name><name sortKey="Yang, Li" sort="Yang, Li" uniqKey="Yang L" first="Li" last="Yang">Li Yang</name><name sortKey="Zhang, Junpeng" sort="Zhang, Junpeng" uniqKey="Zhang J" first="Junpeng" last="Zhang">Junpeng Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Shuyi" sort="Zhang, Shuyi" uniqKey="Zhang S" first="Shuyi" last="Zhang">Shuyi Zhang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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